[left]Location(s) of cholinergic synaptic sites:
? neuromuscular junction
? autonomic effector sites innervated by post-ganglionic sympathetic fibers
? some CNS synapses
? A & C
? B & C
Factors that limit CNS effects of systemic acetylcholine: administration:
? poor CNS penetration
? inactivation by plasma butrylcholinesterase
? both
? neither
Localization of muscarinic cholinergic receptors:
? postganglionic parasympathetic effector sites
? autonomic ganglia cells
? adrenal medulla
? A & C
? A, B & C
Cholinergic receptor type primarily localized at skeletal muscle neuromuscular junctions:
? muscarinic
? nicotinic
Highly sensitive to the action of acetylcholinesterase:
? carbachol
? bethanechol (Urecholine)
? acetylcholine
? A & C
? A,B, & C
Muscarinic receptor subtype primarily associated with the heart:
? M1
? M2
? M3
? M4
Effective antagonist at neuromuscular junction receptors;
? atropine
? tubocurarine
Most likely to be effective in blocking all ganglionic neurotransmission:
? tubocurarine
? mecamylamine (Inversine)
? atropine
? all of the above
Cardiac muscarinic Type M2-receptor mediated action(s):
? increased phase 4 depolarization rate
? increased AV nodal conduction velocity
? Decreased atrial and ventricular contractility
? all the above
Ligand-gated ion channels:
? nicotinic
? muscarinic
? both
? neither
Tends to cause fast responses:
? nicotinic
? muscarinic
Agonist effects blocked by tubocurarine:
? muscarinic receptors
? nicotinic receptors
Indirect-acting cholinomimetic:
? atropine
? edrophonium (Tensilon)
? carbachol
? acetylcholine
? ephedrine
موضوع: امتحان التانى mcq cholinergic drugs 
الجمعة أكتوبر 16, 2009 2:30 pm
