Sympathetic Nervous System
? Ganglionic neurotransmitter: acetylcholine
? generalized response upon sympathetic activation
? thoraco-lumbar origin for preganglionic cell bodies
? A, B and C
Choline ester most susceptible to hydrolysis by acetylcholinesterase:
? carbachol
? acetylcholine
? methacholine (Provocholine)
? pilocarpine (Pilocar)
Resistant to hydrolysis by acetylcholinesterase
? carbachol (carbamylcholine)
? methacholine (Provocholine)
? both
? neither
Highest nicotinic receptor activity among choline esters:
? acetylcholine
? atropine
? methacholine (Provocholine)
? carbachol
Associated with parasympathetic activation (direct effects):
? increase heart rate
? decreased GI motility
? decrease cardiac contractility
? urinary retention
Bronchoconstriction in an asthmatic:
? metoprolol (Lopressor)
? atropine
? albuterol (Ventolin,Proventil)
? ipratropium (Atrovent)
Miosis
? pilocarpine (Pilocar)
? atropine
? both
? neither
Antimuscarinic drug with highest CNS activity
? atropine
? scopolamine
? homatropine
? muscarine
Muscarinic agent: enhances transmission through the A-V node:
? isoproterenol (Isuprel)
? atropine
? propranolol (Inderal)
? methacholine (Provocholine)
Least likely to be used as a mydriatic because of long-duration of action:
? homatropine (Isopto Homatropine)
? atropine
? cyclopentolate (Cyclogyl)
? benztropine (Cogentin)
Clinically-used to treat sinus bradycardia secondary to acute myocardial infarction:
? homatropine (Isopto Homatropine)
? atropine
? benztropine (Cogentin)
? tropicamide (Mydriacyl)
Reflex bradycardia secondary to an abrupt increase in blood pressure may be blocked by:
? atropine
? mecamylamine (Inversine)
? both
? neither
Symptoms following DFP exposure (diisopropylfluorophosphate, an organophosphate poison):
? constipation
? salivation
? decreased gastric acid secretion
? none of the above
موضوع: mcqل cholinergic drugs 
الجمعة أكتوبر 16, 2009 2:24 pm
