امتحانmcqرقم4

51. A drug that is administered orally for treatment of infections by
dermatophytes is :
a. Nystatin
b. Griseofulvin
c. Clotrimazole
d. Miconazole
e. Tolnaftate
Key: b


Table of Specification: MCQ No. 52 – 55.

52. Which of the following antineoplastic drugs is an antimetabolite :
a. Carmustine
b. Busulphan
c. Cisplatin
d. Fluorouracil
e. Vincristine
Key: d


53. The main mechanism of antineoplastic action of the
anthracycline antibiotics is:
a. Binding with tubulin of the cancer cells
b. Inhibition of folic acid metabolism in cancer cells
c. Alkylation of reactive radicals in cancer cells
d. Intercalation of the DNA molecule in cancer cells
e. Disruption of the ribosomes in cancer cells
Key: d


54. Among the alkaloids of Vinca rosea:
a. Vinblastine cause more neurotoxicity than vincristine
b. Vincristine causes more bone marrow depression than vinblastine
c. Vincristine is more useful in childhood leukemias
d. Vinblasti ne has mechanism of action different than vincristine
e. The clinical uses of the two alkaloids are practically the same.
Key: c


55. Which of the following drugs used in chemotherapy of breast
cancer acts by inhibiyting the Estrogen receptor?
a. Diethylstilbestrol
b. Tamoxifen
c. Anastrozole
d. Paclitaxel
e. Cyclophosphamide
Key: b




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MBBS SECOND PROFESSIONAL EXAMINATION 2007
PHARMACOLOGY AND THERAPEUTICS (MCQs)
MODEL PAPER

Table of Specification: MCQ No. 56 – 62

56. Dexamethasone:
a. Is less potent than prednisolone
b. Also has mineralocorticoid activity
c. Improves glucose tolerance
d. Is a naturally occurring glucocort icoid
e. Suppresses hypothalamo-hypophysio-adrenal axis
Key: e


57. Which of the following Insulin preparations has the longest
duration of action?
a. Insulin aspart
b. NPH Insulin
c. Insulin Zinc Suspension Lente
d. Glargine
e. Glulisine
Key: d


58. Which of the followin g Insulin secretogogues is not a
Sulfonylurea in its chemical structure?
a. Chlorpropamide
b. Nateglinide
c. Glibenclamide
d. Glipizide
e. Glimepiride
Key: b


59. Which of the following antidiabetic drugs acts by binding with
PPAR -g receptor?
a. Metformin
b. Acarbose
c. Repaglinide
d. Pioglitazone
e. Gliclizide
Key: d


60. The mechanism of atithyroid action of Propylthiouracil is to:
a. Inhibit iodination of the tyrosil residues
b. Inhibit coupling of the iodotyrosil residues
c. Inhibit peroxidase enzyme in thyroid gland
d. Reduce the circulating Thyroid-stimulating immunoglobulins
e. All of the above
Key: e




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MBBS SECOND PROFESSIONAL EXAMINATION 2007
PHARMACOLOGY AND THERAPEUTICS (MCQs)
MODEL PAPER

61. The most serious adverse reaction that may occur with the use
of Thionamide antithyroid drugs is:
a. Agranulocytosis
b. Joint pains
c. Paresthesias
d. Alopecia
e. Skin rashes
Key: a


62. The radio-active Iodine131:
a. Exerts atithyroid action by emitting gamma radiation
b. Is most suitable for young adult male patients
c. Is safe for use during pregnancy
d. May cause delayed hypothyroidism
e. Has a rapid onset of action
Key: d


Table of Specification: MCQ No. 63- 65

63. A taxi driver comes to the clinic with complaints of runny nose,
effused eyes, fever and malaise. He wishes to continue his work
while taking treatment for these symptoms. Which one of the
following anti histamines would be most suitable for him?
a. Chlorpheniramine
b. Diphenhydramine
c. Fexofenadine
d. Meclizine
e. Hydroxyzine
Key: c


64. A drug that is administered systemically for the treatment of
acute glaucoma is:
a. Timolol
b. Acetazolamide
c. Physostigmine
d. Demecarium
e. Latanoprost
Key: b


65. Which of the following chelators has been correctly paired with
the metal for whose poisoning it is clinically used?
a. Edetate Calcium Disodium --- Mercury
b. Dimercaprol --- Arsenic
c. Succimer --- Gold
d. Penicillamine --- Silver
e. Deferoxamine --- Lead
Key: b